# How to interpret enriched lineage?

**URL:** <https://forum.depmap.org/t/how-to-interpret-enriched-lineage/2826>\
**Category:** Q&A\
**Created:** [September 22, 2023, 3:10am UTC](https://forum.depmap.org/t/how-to-interpret-enriched-lineage/2826 "2023-09-22T03:10:01Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![zll](https://avatars.discourse-cdn.com/v4/letter/z/a6a055/32.png) [@zll](https://forum.depmap.org/u/zll)\
**Post date:** [September 22, 2023, 3:10am UTC](https://forum.depmap.org/t/how-to-interpret-enriched-lineage/2826/1 "2023-09-22T03:10:01Z")

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Hi,

I’m new to DepMap and would like to ask how to interpret the p-value of enriched lineage. I read the previous threads and understand the p is calculated by using a t-test to compare the gene effects in selected cell lineages with all other lineages, so does it mean that if a gene has a small p-value, the gene is “specific” to this cell lineage?

Besides, I also noticed the genes with effects below -1 / -0.5 only partially match genes with small p-values in any lineage, so should we focus on genes both more “specific” (smaller p) and more dependent (larger negative gene effect) to a specific cell lineage?

Any guidance would be highly appreciated.

Thank you!