# HCC1395: implausible ploidy estimate

**URL:** https://forum.depmap.org/t/hcc1395-implausible-ploidy-estimate/458
**Category:** Report an Issue
**Created:** [February 17, 2021, 4:01pm UTC](https://forum.depmap.org/t/hcc1395-implausible-ploidy-estimate/458 "2021-02-17T16:01:24Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![max](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/max/32/177_2.png) [@max](https://forum.depmap.org/u/max)
#### Post date: [February 17, 2021, 4:01pm UTC](https://forum.depmap.org/t/hcc1395-implausible-ploidy-estimate/458/1 "2021-02-17T16:01:25Z")

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Thank you for the incredible resource! I was looking at the ploidy entry for the HCC1395 cell line in CCLE\_ABSOLUTE\_combined\_20181227.xlsx, and it reports an estimate of 1.48. This seems highly unlikely, as the karyotype analysis for this cell line performed by the The Somatic Working Group of SEQC-II Consortium suggests it is hypertetraploid. For details, see: [https://www.biorxiv.org/content/10.1101/626440v3.supplementary-material](https://www.biorxiv.org/content/10.1101/626440v3.supplementary-material)

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### Author: ![jmmcfarl](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/jmmcfarl/32/16_2.png) [@jmmcfarl](https://forum.depmap.org/u/jmmcfarl)
#### Post date: [March 4, 2021, 7:57pm UTC](https://forum.depmap.org/t/hcc1395-implausible-ploidy-estimate/458/2 "2021-03-04T19:57:26Z")

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Thanks for pointing this out Max!  
These ABSOLUTE data were generated as part of the CCLE2 [paper](https://www.nature.com/articles/s41586-019-1186-3). We aren’t currently estimating ploidy ourselves, so we just provide those data as a resource. Generating new estimates of ploidy is on our radar though.