# Gene effect vs dependent cell lines

**URL:** <https://forum.depmap.org/t/gene-effect-vs-dependent-cell-lines/699>\
**Category:** Q&A\
**Created:** [June 30, 2021, 12:51pm UTC](https://forum.depmap.org/t/gene-effect-vs-dependent-cell-lines/699 "2021-06-30T12:51:04Z")\
**Posts on this page:** 2\
**Page:** 1

<div class="post-metadata">

**Author:** ![spirozoltan](https://avatars.discourse-cdn.com/v4/letter/s/f475e1/32.png) [@spirozoltan](https://forum.depmap.org/u/spirozoltan)\
**Post date:** [June 30, 2021, 12:51pm UTC](https://forum.depmap.org/t/gene-effect-vs-dependent-cell-lines/699/1 "2021-06-30T12:51:04Z")

</div>

Hello,  
Is there a way to identify the dependent cell lines sensitive to the CRISPR KO of a given gene based on its corresponding CERES scores? There are less number of cell lines with CERES \<-0.5 than what is displayed on the overview tab of a given gene. Eg. in the case of BRCA1: number of dependent cell lines **548** , cell lines with CERES less, than -0.5: **474**  
Should we simply take the first x number of cell lines you categorized as dependent from the CERES table?  
Thanks a lot for your support,  
Zoltan Spiro

---

<div class="post-metadata">

**Author:** ![Joshua\_Dempster](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/joshua_dempster/32/19_2.png) [@Joshua\_Dempster](https://forum.depmap.org/u/Joshua_Dempster)\
**Post date:** [July 1, 2021, 2:14pm UTC](https://forum.depmap.org/t/gene-effect-vs-dependent-cell-lines/699/2 "2021-07-01T14:14:18Z")

</div>

Hi Zoltan, see [How is the # of Dependent Cell Lines a gene is essential for calculated?](https://forum.depmap.org/t/how-is-the-of-dependent-cell-lines-a-gene-is-essential-for-calculated/519)