# Gene effect on sensitivity to PARP inhibitors

**URL:** <https://forum.depmap.org/t/gene-effect-on-sensitivity-to-parp-inhibitors/2515>\
**Category:** Q&A\
**Created:** [May 2, 2023, 7:54pm UTC](https://forum.depmap.org/t/gene-effect-on-sensitivity-to-parp-inhibitors/2515 "2023-05-02T19:54:54Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Camilo\_Tapia](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/camilo_tapia/32/821_2.png) [@Camilo\_Tapia](https://forum.depmap.org/u/Camilo_Tapia)\
**Post date:** [May 2, 2023, 7:54pm UTC](https://forum.depmap.org/t/gene-effect-on-sensitivity-to-parp-inhibitors/2515/1 "2023-05-02T19:54:54Z")

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Hi, I am trying to find out if some genes are related to sensitivity to PARP inhibitors in the context of breast cancer, so I have some doubts:

- In a CRISPR vs Drug sensitivity plot, which parameter would be the best indicator of this sensitivity? would it be the correlation coefficient (pearson or spearman as appropriate)?
- is there a more appropriate comparison that would fit better the purpose of my investigation?  
Thanks in advance.  
Camilo