# Gene dependency score of RNAi screening data (DEMETER2)

**URL:** <https://forum.depmap.org/t/gene-dependency-score-of-rnai-screening-data-demeter2/1395>\
**Category:** Q&A\
**Created:** [May 13, 2022, 6:33am UTC](https://forum.depmap.org/t/gene-dependency-score-of-rnai-screening-data-demeter2/1395 "2022-05-13T06:33:50Z")\
**Posts on this page:** 4\
**Page:** 1

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**Author:** ![ujd913](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/ujd913/32/422_2.png) [@ujd913](https://forum.depmap.org/u/ujd913)\
**Post date:** [May 13, 2022, 6:33am UTC](https://forum.depmap.org/t/gene-dependency-score-of-rnai-screening-data-demeter2/1395/1 "2022-05-13T06:33:51Z")

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Hi,

The value of D2\_combined\_gene\_dep\_scores.csv seems to be a gene effect, not a gene dependency. Is there no gene dependency data with a value of 0 to 1 like the dependency score of CRISPR\_gene\_dependency.csv?

Thanks.

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**Author:** ![Joshua\_Dempster](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/joshua_dempster/32/19_2.png) [@Joshua\_Dempster](https://forum.depmap.org/u/Joshua_Dempster)\
**Post date:** [May 16, 2022, 4:20pm UTC](https://forum.depmap.org/t/gene-dependency-score-of-rnai-screening-data-demeter2/1395/2 "2022-05-16T16:20:21Z")

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You can find more DepMap-like versions of the combined RNAi dataset (following the conventions of the CRISPR datasets for gene\_dependency and gene\_effect) at [DEMETER 2 Combined RNAi](https://figshare.com/articles/dataset/DEMETER_2_Combined_RNAi/9170975).

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<div class="post-metadata">

**Author:** ![ujd913](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/ujd913/32/422_2.png) [@ujd913](https://forum.depmap.org/u/ujd913)\
**Post date:** [May 20, 2022, 6:06am UTC](https://forum.depmap.org/t/gene-dependency-score-of-rnai-screening-data-demeter2/1395/3 "2022-05-20T06:06:51Z")

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@Joshua_Dempster Thanks for your answer. I have a question about the gene dependency of the link you provided. Like the dependency score of CRISPR, can this dependency score be considered dependent if it is 0.5 or higher?

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**Author:** ![Joshua\_Dempster](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/joshua_dempster/32/19_2.png) [@Joshua\_Dempster](https://forum.depmap.org/u/Joshua_Dempster)\
**Post date:** [May 20, 2022, 1:05pm UTC](https://forum.depmap.org/t/gene-dependency-score-of-rnai-screening-data-demeter2/1395/4 "2022-05-20T13:05:16Z")

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As with the CRISPR data, 0.5 means an estimated 50% probability that the gene score represents a true dependency.