# Discovering Compensatory Mechanisms

**URL:** <https://forum.depmap.org/t/discovering-compensatory-mechanisms/2925>\
**Category:** Q&A\
**Created:** [November 20, 2023, 2:21pm UTC](https://forum.depmap.org/t/discovering-compensatory-mechanisms/2925 "2023-11-20T14:21:45Z")\
**Posts on this page:** 2\
**Page:** 1

<div class="post-metadata">

**Author:** ![MathewSchneider](https://avatars.discourse-cdn.com/v4/letter/m/f19dbf/32.png) [@MathewSchneider](https://forum.depmap.org/u/MathewSchneider)\
**Post date:** [November 20, 2023, 2:21pm UTC](https://forum.depmap.org/t/discovering-compensatory-mechanisms/2925/1 "2023-11-20T14:21:45Z")

</div>

I am new to this tool and am trying to identify compensatory mechanisms for my gene of interest. When ever I try to look at expression, it only shows different cell lines. How can I look at upregulated genes in response to KO of my gene of interest?

---

<div class="post-metadata">

**Author:** ![pmontgom](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/pmontgom/32/4_2.png) [@pmontgom](https://forum.depmap.org/u/pmontgom)\
**Post date:** [November 21, 2023, 1:47pm UTC](https://forum.depmap.org/t/discovering-compensatory-mechanisms/2925/2 "2023-11-21T13:47:16Z")

</div>

In the DepMap, we are only collecting the effect on viability due to knocking out a gene. It sounds like you’re interested in the change to expression due to knocking out a gene, but that is not data that we collect in our current assay.

We do have expression data for most cell lines, but that was collected pre-perturbation. The only we readout we have post-perturbation is viabilitiy.

Thanks,  
Phil