# Difference between gene effects/dependency files

**URL:** <https://forum.depmap.org/t/difference-between-gene-effects-dependency-files/688>\
**Category:** Q&A\
**Tags:** data\
**Created:** [June 25, 2021, 8:06am UTC](https://forum.depmap.org/t/difference-between-gene-effects-dependency-files/688 "2021-06-25T08:06:46Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![abct](https://avatars.discourse-cdn.com/v4/letter/a/94ad74/32.png) [@abct](https://forum.depmap.org/u/abct)\
**Post date:** [June 25, 2021, 8:06am UTC](https://forum.depmap.org/t/difference-between-gene-effects-dependency-files/688/1 "2021-06-25T08:06:46Z")

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Hello!  
On my way to download the 21Q2 datasets, I saw that there are several versions of the gene effects and dependency files.

First, there are the Achilles/CRISPR difference: as far as I understand the readme, `Achilles_gene_dependency.csv` use only data from Broad Institute whereas `CRISPR_gene_dependency.csv` combines these data with data from Sanger Institute.

Second, there is a difference in the gene fitness inference method used. `Achilles_gene_dependency.csv` uses CERES, the old preprocessor, whereas `Achilles_gene_dependency_Chronos.csv` uses Chronos, [the new one](https://cancerdatascience.org/blog/posts/ceres-chronos/).

So, if I want only data from Broad Institute DepMap and the newest pipeline, I should use `Achilles_gene_[dependency|effect]_Chronos.csv`, right?  
And as Chronos provides significant improvements, will CERES-analysed datasets continue to be provided?

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**Author:** ![iboyle](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/iboyle/32/69_2.png) [@iboyle](https://forum.depmap.org/u/iboyle)\
**Post date:** [June 25, 2021, 8:17pm UTC](https://forum.depmap.org/t/difference-between-gene-effects-dependency-files/688/2 "2021-06-25T20:17:21Z")

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Hello!

You are correct that there are Achilles (Broad) and CRIPSR (Broad+Sanger) datasets for both CERES and Chronos in the 21Q2 release, and that the Achilles\_gene\_dependency/effect\_Chronos file is the Broad DepMap data from the newest pipeline this quarter.

We will no longer run CERES, so in future releases all Achilles files will be processed by Chronos. The naming convention for these files will change as Chronos becomes the default, for example Achilles\_gene\_dependency\_Chronos will be named Achilles\_gene\_dependency in 21Q3.

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**Author:** ![abct](https://avatars.discourse-cdn.com/v4/letter/a/94ad74/32.png) [@abct](https://forum.depmap.org/u/abct)\
**Post date:** [June 25, 2021, 10:00pm UTC](https://forum.depmap.org/t/difference-between-gene-effects-dependency-files/688/3 "2021-06-25T22:00:31Z")

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Thanks for your precisions!