# DepMap Quarterly Release Notes **URL:** \ **Category:** Release Notes\ **Created:** [September 9, 2024, 9:04pm UTC](https://forum.depmap.org/t/depmap-quarterly-release-notes/3560 "2024-09-09T21:04:40Z")\ **Posts on this page:** 1\ **Page:** 1
**Author:** ![Samantha\_Stokes](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/samantha_stokes/32/676_2.png) [@Samantha\_Stokes](https://forum.depmap.org/u/Samantha_Stokes)\ **Post date:** [September 9, 2024, 9:04pm UTC](https://forum.depmap.org/t/depmap-quarterly-release-notes/3560/1 "2024-09-09T21:04:40Z")
### DepMap releases data bi-annually to the DepMap Portal, along with new tools and other resources for you to explore. Read more about each release below. ### 26Q1 **Highlights** - 25 new genome-wide CRISPR screens and Omics for Adult and Pediatric models - Subtype tree updates for CNS models [(October 9, 2025 OncoTree update)](https://oncotree.mskcc.org/news) - Updates to CRISPR pipeline for library correction - Updates to Mutation pipeline for variant filtering and hotspots - Context Manager update to allow for all metadata types to be used when defining contexts - New Tool! [GeneTEA](https://pmc.ncbi.nlm.nih.gov/articles/PMC12577433/) uses natural language processing to uncover biology across the portal Read the full release notes [here](https://forum.depmap.org/t/announcing-the-26q1-release/4606). ### 25Q3 **Highlights** - 3 new CRISPR screens including adult and pediatric models - Additional WGS and other Omics for models - Updates to CRISPR screen processing pipeline - Update to OmicsMapping files - New Tool! Context Explorer enables researchers to explore enriched genetic dependencies and compound sensitivities across cancer lineages and subtypes. Read the full release notes [here](https://forum.depmap.org/t/announcing-the-25q3-release/4476). ### 25Q2 **Highlights** - 5 new CRISPR screens including adult and pediatric models - Additional WGS and other Omics for models - Updates to re-processing of Humagne screens and removal of 9 Humagne guides - Update to OmicsMapping file to include default profiles shown in DE2 - Updates to all Omics pipelines (Copy Number, Mutation, Expression and Fusion) - Reorganization of Context Manager to allow for use of more metadata columns to make contexts Read the full release notes [here](https://forum.depmap.org/t/announcing-the-25q2-release/4257/3). ### 24Q4 **Highlights** - 35 new CRISPR screens including adult and pediatric models - New WGS effort for all DepMap models with CRISPR screens - Re-processing of Humagne screens, change to SequenceMaxCorr metric and updates to pDNA batch metadata - New Resources page - Change to standardize and consolidate file names and dataset versions on the Downloads page Read the full release notes [here](https://forum.depmap.org/t/announcing-the-24q4-release/3564). ### 24Q2 **Highlights** - Data Explorer 2.0 - Centralized Data Hub in the portal - New genomic features: PureCN absolute copy number data and Omics Signatures - This PRISM Repurposing dataset now contains two screens - New “pDNA” reference for Humagne screens - Refinment of sequence correlation QC metric - Omics pipeline updates - RNA-strandness correction Read the full release notes [here](https://forum.depmap.org/t/announcing-the-24q2-release/3312). ### 23Q4 **Highlights** - New CRISPR Cas12 dual-guide Humage library - Updates to mutation pipeline for better germline filtering and more comprehensive rescuing of cancer-related variants. - Legacy Copy Number from SNParray dropped - New profile-level expression (TPM) files - Removal of Confounding Components (RCPC) for Screen Quality Correction - Celligner app update Read the full release notes [here](https://forum.depmap.org/t/announcing-the-23q4-release/2929/2). ### 23Q2 **Highlights** - New metadata columns - Standardized media annotations - New Target Discovery app - OmicsSomaticMutationsMAFProfile.maf now available Read the full release notes [here](https://forum.depmap.org/t/announcing-the-23q2-release/2518). ### 22Q4 **Highlights** - New Oncotree annotations for cell lines - Updated data structure including introduction of Model Conditions - Gene set enrichment included as part of release files - Omics pipeline updates - CRISPR data produced by joint Chronos run on all included Screens for a Model in different conditions - New CRISPR NaiveScreenEffect file - Release of binary mutation matrices for locations in the guide libraries (KY, Avana and Humagne) used for Achilles’ ancestry bias correction - Updates to Achilles QC to include: SequenceMeanReadsPerGuide, - SequenceNNMD/ScreenNNMD, and SequenceMaxCorr - Removal of legacy SNP-based copy number calling and hybrid capture/raindance-based mutation calling Read the full release notes [here](https://forum.depmap.org/t/announcing-the-22q4-release/2125).