# Dependencies enriched files/ t-statistic and p-value columns 

**URL:** <https://forum.depmap.org/t/dependencies-enriched-files-t-statistic-and-p-value-columns/2277>\
**Category:** Q&A\
**Created:** [February 8, 2023, 2:24pm UTC](https://forum.depmap.org/t/dependencies-enriched-files-t-statistic-and-p-value-columns/2277 "2023-02-08T14:24:50Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Suad\_Alshammari](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/suad_alshammari/32/773_2.png) [@Suad\_Alshammari](https://forum.depmap.org/u/Suad_Alshammari)\
**Post date:** [February 8, 2023, 2:24pm UTC](https://forum.depmap.org/t/dependencies-enriched-files-t-statistic-and-p-value-columns/2277/1 "2023-02-08T14:24:50Z")

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Hello everyone,  
Recently I started using depmap to check the best-targeted kinase for some cancers. After downloading Dependencies enriched files, I got a table with t-statistic and p-value columns (as seen below). I tried to find answers about what they refer to and how they are calculated, but I could not find any answers.  
Also, what is the best way to find the targeted kinase (is it the lowest t-statistic or p-value)?  
Please help me with this.

 ![image](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/1X/d5e9b1be2b440024f021e0be8fbdf8c4061417c2.png)

Thank you!

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**Author:** ![vidat](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/vidat/32/780_2.png) [@vidat](https://forum.depmap.org/u/vidat)\
**Post date:** [February 8, 2023, 6:28pm UTC](https://forum.depmap.org/t/dependencies-enriched-files-t-statistic-and-p-value-columns/2277/2 "2023-02-08T18:28:51Z")

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`run_lm_stats_limma` function in this code is used to calculate these numbers.  
[linear\_association.R](https://github.com/broadinstitute/cdsr_models/blob/master/R/linear_association.R)  
[another question on the forum on this](https://forum.depmap.org/t/details-on-methodology-of-two-class-comparison/211)  
There is a table for each cell line group (cancer lineage) e.g. lung cancer, that shows which gene/compounds are enriched in that group vs. all other cells. The enriched lineages for CRISPR and RNAi datasets are shown as a boxplot on the summary page when you search a gene.