# CRISPR screens data for a drug effect

**URL:** <https://forum.depmap.org/t/crispr-screens-data-for-a-drug-effect/3142>\
**Category:** Q&A\
**Created:** [March 18, 2024, 5:03pm UTC](https://forum.depmap.org/t/crispr-screens-data-for-a-drug-effect/3142 "2024-03-18T17:03:09Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![sherma1](https://avatars.discourse-cdn.com/v4/letter/s/9de053/32.png) [@sherma1](https://forum.depmap.org/u/sherma1)\
**Post date:** [March 18, 2024, 5:03pm UTC](https://forum.depmap.org/t/crispr-screens-data-for-a-drug-effect/3142/1 "2024-03-18T17:03:09Z")

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Hi, I am interested in results of the CRISPR screens that identify genes that modulate the response (protect or sensitize) to osimertinib in a sensitive cell line. How can I find these data?

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**Author:** ![pmontgom](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/pmontgom/32/4_2.png) [@pmontgom](https://forum.depmap.org/u/pmontgom)\
**Post date:** [April 5, 2024, 1:04pm UTC](https://forum.depmap.org/t/crispr-screens-data-for-a-drug-effect/3142/2 "2024-04-05T13:04:08Z")

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It sounds like you are interested in what I hear referred to as “anchor screens”. (ie: CRISPR screens in the presence of a drug which can be compared to response without the drug) However, none of the released DepMap data contain anchor screens.

The released DepMap CRISPR screens are all measuring the knockout of genes in the under that cell line’s growth conditions.

Thanks,  
Phil

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**Author:** ![sherma1](https://avatars.discourse-cdn.com/v4/letter/s/9de053/32.png) [@sherma1](https://forum.depmap.org/u/sherma1)\
**Post date:** [April 5, 2024, 3:18pm UTC](https://forum.depmap.org/t/crispr-screens-data-for-a-drug-effect/3142/3 "2024-04-05T15:18:47Z")

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Hi Phil,  
Thank you very much,  
Michael