# BRCA1/BRCA2 - Achilles common essential

**URL:** <https://forum.depmap.org/t/brca1-brca2-achilles-common-essential/1349>\
**Category:** Q&A\
**Created:** [April 25, 2022, 8:08am UTC](https://forum.depmap.org/t/brca1-brca2-achilles-common-essential/1349 "2022-04-25T08:08:52Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Otto\_Morris](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/otto_morris/32/465_2.png) [@Otto\_Morris](https://forum.depmap.org/u/Otto_Morris)\
**Post date:** [April 25, 2022, 8:08am UTC](https://forum.depmap.org/t/brca1-brca2-achilles-common-essential/1349/1 "2022-04-25T08:08:52Z")

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Hi,

Thanks so much for all your work supporting this fantastic project.

Apologies if this question has previously been addressed, but I am uncertain why BRCA1 and BRCA2 are annotated as common essential genes in the downloadable “Achilles\_common\_essential.csv” but not when browsing the website GUI?

Thanks,

Otto.

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**Author:** ![pmontgom](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/pmontgom/32/4_2.png) [@pmontgom](https://forum.depmap.org/u/pmontgom)\
**Post date:** [April 25, 2022, 2:58pm UTC](https://forum.depmap.org/t/brca1-brca2-achilles-common-essential/1349/2 "2022-04-25T14:58:05Z")

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Hello,

I believe the inconsistency is due to the which dataset is being shown in the portal for that gene, and the file you referenced is for a related, but slightly different dataset.

There are actually multiple CRISPR datasets: one generated at the Broad, “Achilles”, one generated at Sanger, “Score”, and a last dataset which is a harmonized version incorporating data from both Sanger _and_ Broad.

On the gene page, we default to using the largest dataset which has data for the given gene, which for most genes, is the combined dataset.

 ![image](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/1X/b9dedd24752239e1d8d0c01babd927a95dd6629b.png)

(The “CRISPR (DepMap 22Q1 Public+Score, Chronos)” is referring to the merged dataset and indicating what is being shown here is using that data)

So, while BRCA1 and BRCA2 are present in “Achilles\_common\_essentials.csv” (which is derived from _only_ the Broad data), they are missing from “CRISPR\_common\_essentials.csv” (which is derived from the Broad _and_ Sanger data). That suggests that based on the merged dataset these genes did not meet the cutoff and is consistent with what’s being shown on the portal.

Thanks,  
Phil

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<div class="post-metadata">

**Author:** ![Otto\_Morris](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/otto_morris/32/465_2.png) [@Otto\_Morris](https://forum.depmap.org/u/Otto_Morris)\
**Post date:** [April 25, 2022, 7:38pm UTC](https://forum.depmap.org/t/brca1-brca2-achilles-common-essential/1349/3 "2022-04-25T19:38:03Z")

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Thanks Phil! That’s a great help