# Are IC50 values downloadable from DepMap log or z-transformed or normalized in some way? **URL:** \ **Category:** Q&A\ **Tags:** compound-screens\ **Created:** [January 18, 2022, 2:40pm UTC](https://forum.depmap.org/t/are-ic50-values-downloadable-from-depmap-log-or-z-transformed-or-normalized-in-some-way/1143 "2022-01-18T14:40:49Z")\ **Posts on this page:** 2\ **Page:** 1
**Author:** ![Ashutosh\_Pandey](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/ashutosh_pandey/32/398_2.png) [@Ashutosh\_Pandey](https://forum.depmap.org/u/Ashutosh_Pandey)\ **Post date:** [January 18, 2022, 2:40pm UTC](https://forum.depmap.org/t/are-ic50-values-downloadable-from-depmap-log-or-z-transformed-or-normalized-in-some-way/1143/1 "2022-01-18T14:40:49Z")
Hello, I would like to know if IC50 values that can be downloaded as part of the files below are transformed (such as log transformation, z-scores). I couldn’t find any README file that explains how those values were derived. I see the publication links but I would like to know if I need to further normalize them before I can perform any downstream analysis on them. Files: Drug\_sensitivity\_IC50\_(Sanger\_GDSC1) Drug\_sensitivity\_IC50\_(Sanger\_GDSC2) ---
**Author:** ![Mustafa\_Kocak](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/mustafa_kocak/32/11_2.png) [@Mustafa\_Kocak](https://forum.depmap.org/u/Mustafa_Kocak)\ **Post date:** [May 3, 2022, 3:01pm UTC](https://forum.depmap.org/t/are-ic50-values-downloadable-from-depmap-log-or-z-transformed-or-normalized-in-some-way/1143/2 "2022-05-03T15:01:56Z")
Hi Ashutosh, Apologies for the late reply. Today on portal, we have the combined sanger-dose-response.csv file which has the original published IC50 values from the Sanger Institute (in micro molars). My recommendation would be log-transforming them before using them in downstream analysis, but using them as it is also pretty common in the field. Warmly, Mustafa