# ANOVA or Wilcox for the analysis of CRISPR\_gene\_effect.csv?

**URL:** <https://forum.depmap.org/t/anova-or-wilcox-for-the-analysis-of-crispr-gene-effect-csv/1440>\
**Category:** Q&A\
**Created:** [May 31, 2022, 1:57pm UTC](https://forum.depmap.org/t/anova-or-wilcox-for-the-analysis-of-crispr-gene-effect-csv/1440 "2022-05-31T13:57:00Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![cjlin](https://avatars.discourse-cdn.com/v4/letter/c/4bbf92/32.png) [@cjlin](https://forum.depmap.org/u/cjlin)\
**Post date:** [May 31, 2022, 1:57pm UTC](https://forum.depmap.org/t/anova-or-wilcox-for-the-analysis-of-crispr-gene-effect-csv/1440/1 "2022-05-31T13:57:00Z")

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Hi. I’m wondering which of the statistical methods we should use when comparing the CRISPR dependency scores between two groups. ANOVA or WILCOX?

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**Author:** ![Joshua\_Dempster](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/joshua_dempster/32/19_2.png) [@Joshua\_Dempster](https://forum.depmap.org/u/Joshua_Dempster)\
**Post date:** [June 23, 2022, 6:55pm UTC](https://forum.depmap.org/t/anova-or-wilcox-for-the-analysis-of-crispr-gene-effect-csv/1440/2 "2022-06-23T18:55:01Z")

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Currently the portal uses t-tests. Wilcox might be useful if you want to focus on tail behavior, but it’s likely to turn up a lot of apparent differences that turn out to be uninteresting.