# Announcing the 25Q3 Release

**URL:** <https://forum.depmap.org/t/announcing-the-25q3-release/4476>\
**Category:** Announcements\
**Created:** [September 30, 2025, 4:15pm UTC](https://forum.depmap.org/t/announcing-the-25q3-release/4476 "2025-09-30T16:15:56Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Samantha\_Stokes](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/samantha_stokes/32/676_2.png) [@Samantha\_Stokes](https://forum.depmap.org/u/Samantha_Stokes)\
**Post date:** [September 30, 2025, 4:15pm UTC](https://forum.depmap.org/t/announcing-the-25q3-release/4476/1 "2025-09-30T16:15:56Z")

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[![DepMap_Logosize](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/2X/d/da61a70f58a0474a923df5b01e120a8fd070a798.jpeg)](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/2X/d/da61a70f58a0474a923df5b01e120a8fd070a798.jpeg "DepMap\_Logosize")

### 25Q3 DepMap Release Notes

We’re excited to announce the release of new DepMap data and a new tool, Context Explorer, to help you perform context-specific analyses. We’ve also made important updates to our Omics and CRISPR pipelines. Please read the release note below for more information.

**NEW DEPMAP DATASETS AND FEATURES**

**Standard Release Data**

- We’ve added 9 new paired WGS/RNA profiles and 3 new genome-wide CRISPR KO screens in rare and pediatric cancers, and 7 new Sanger KY screens.

**BioGRID Open Repository of CRISPR Screens** ([https://orcs.thebiogrid.org/](https://orcs.thebiogrid.org/))

- A new BioGrid dataset is available on the portal containing the results of 22 genome-scale CRISPR knockout screens using TKOv3 Cas9 or Brunello Cas9 libraries.

- This dataset is currently available for download only.

**NEW TOOLS**

- **Context Explorer**

 ![image](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/2X/9/9b2cea7b711ed1e5716c9062dc1a67866aff0cb0.png)

**CRISPR PIPELINE UPDATES**

- **Sequencing technology batching for Chronos Runs**

**OMICS PIPELINE UPDATES**

- Users will notice the following streamlined Omics outputs for ease of use and to avoid redundancy:

- Mutation Pipeline

- New column in **OmicsProfile.csv** :

**PORTAL UPDATES**

- **Bug fixes and minor updates**

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<div class="post-metadata">

**Author:** ![Samantha\_Stokes](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/samantha_stokes/32/676_2.png) [@Samantha\_Stokes](https://forum.depmap.org/u/Samantha_Stokes)\
**Post date:** [October 2, 2025, 2:37pm UTC](https://forum.depmap.org/t/announcing-the-25q3-release/4476/2 "2025-10-02T14:37:10Z")

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