# Announcing the 25Q2 Release

**URL:** <https://forum.depmap.org/t/announcing-the-25q2-release/4257>\
**Category:** Announcements\
**Created:** [June 5, 2025, 5:10pm UTC](https://forum.depmap.org/t/announcing-the-25q2-release/4257 "2025-06-05T17:10:43Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Samantha\_Stokes](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/samantha_stokes/32/676_2.png) [@Samantha\_Stokes](https://forum.depmap.org/u/Samantha_Stokes)\
**Post date:** [June 5, 2025, 5:10pm UTC](https://forum.depmap.org/t/announcing-the-25q2-release/4257/1 "2025-06-05T17:10:43Z")

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![DepMap_Logosize](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/2X/d/da61a70f58a0474a923df5b01e120a8fd070a798.jpeg)

### **25Q2 Public DepMap Release Notes**

In this release, we have added new CRISPR and Omics data, more WGS data for lines that previously had WES and important updates to our Omics and CRISPR pipelines.

Please read the release note below for more information.

### MODEL ANNOTATIONS

- We’ve added new metadata columns:
  - New Columns
    - Model.csv
      - ModelIDAlias (Freetext): Previously known Model IDs (ACH-XXXXXX) used to reference the model, in cases when models are merged due to possible fingerprint swaps, duplication, etc.
      - PediatricModelType (Boolean): Indicates if this model represents a pediatric cancer subtype based on molecular features rather than age alone.

    - Modified Columns
      - ModelAvailableInDbgap (Controlled Vocab): terms have been updated to reflect the appropriate level of access across databases where sequencing data may be available.

### NEW DEPMAP DATA

**Standard Release Data**

We’ve added 11 new paired WGS/RNA profiles and 5 new genome-wide CRISPR KO screens, including new models of pediatric cancers as part of our Pediatric Cancer Dependency (PedDep) Accelerator initiative (see [PedDep.org](http://peddep.org/) for details of this collaboration).

**WGS sequencing effort**

We are releasing the next set of 155 WGS that are now available on the portal. These DepMap WGS will become the default genomic profile for DepMap models in the portal.

### CRISPR PIPELINE UPDATES

- Reprocessing Humagne Readcounts

- Changes to Humagne Guides

### OMICS PIPELINE UPDATES

We’ve made significant updates across our Omics pipelines.

**Mapping files changes**

- OmicsProfiles.csv [master mapping file]

- OmicsDefaultModelProfiles.csv

- OmicsDefaultModelConditionProfiles.csv

- Synchronization of genome annotation files

- Mutation Pipeline:

- Copy Number Pipeline:

- Expression Pipeline:

- Fusion Pipeline:

- The file “OmicsFusionUnfilteredProfile.csv” will no longer be released and all qualified fusions will be present in OmicsFusionFiltered\_supplementary.csv

### PORTAL UPDATES

- Context Manager reorganization
  - Context manager has received a reorganization as we prepare to incorporate more metadata into the tool and update it to use consistent nomenclature with the metadata column names that you’ll find in the downloadable files. In this release, you can still find the old names listed under “Legacy Annotation” but the new names for these properties, and match the column names in downloads are listed under “Annotations”.

- Bug fixes and minor updates:
  - Previously, the “common essential” badge shown on the gene page was based on a separate implementation of the same methodology that Chronos is using. However, due to small differences in implementation, some genes were inconsistent with the set of genes that Chronos reported. The portal has been updated to use the set of genes Chronos reports instead of recomputing the common essential genes.
  - Custom analysis previously reported an internal error if there were no overlaps between the in or out groups and the dataset interrogated. This has been fixed and replaced with an error message explaining the specified groups cannot be used with the dataset due to lack of overlap.

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<div class="post-metadata">

**Author:** ![Samantha\_Stokes](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/samantha_stokes/32/676_2.png) [@Samantha\_Stokes](https://forum.depmap.org/u/Samantha_Stokes)\
**Post date:** [June 5, 2025, 5:10pm UTC](https://forum.depmap.org/t/announcing-the-25q2-release/4257/2 "2025-06-05T17:10:47Z")

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<div class="post-metadata">

**Author:** ![Samantha\_Stokes](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/samantha_stokes/32/676_2.png) [@Samantha\_Stokes](https://forum.depmap.org/u/Samantha_Stokes)\
**Post date:** [June 30, 2025, 4:04pm UTC](https://forum.depmap.org/t/announcing-the-25q2-release/4257/3 "2025-06-30T16:04:13Z")

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