# 26Q1 OmicsCNGeneWGS.csv normalization

**URL:** <https://forum.depmap.org/t/26q1-omicscngenewgs-csv-normalization/4656>\
**Category:** Q&A\
**Created:** [July 17, 2026, 3:02am UTC](https://forum.depmap.org/t/26q1-omicscngenewgs-csv-normalization/4656 "2026-07-17T03:02:31Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![bikeuphill](https://avatars.discourse-cdn.com/v4/letter/b/49beb7/32.png) [@bikeuphill](https://forum.depmap.org/u/bikeuphill)\
**Post date:** [July 17, 2026, 3:02am UTC](https://forum.depmap.org/t/26q1-omicscngenewgs-csv-normalization/4656/1 "2026-07-17T03:02:31Z")

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In the 26Q1 OmicsCNGeneWGS.csv release, what is the reported linear copy number ratio normalized against? Does a ratio of ~1.0 incorporate that specific cell line’s own ploidy (e.g. a value of ~1.0 for an unaltered gene in a tetraploid line, since 4 copies is ‘normal’ for that line, while a value of ~2.0 could mean 4 copies in a diploid line but 8 copies in a tetraploid line)? I want to use the data to define cell lines with loss or amplification of genes of interest and want to make sure I am interpreting the values correctly.

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**Author:** ![simz](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/simz/32/440_2.png) [@simz](https://forum.depmap.org/u/simz)\
**Post date:** [July 17, 2026, 1:09pm UTC](https://forum.depmap.org/t/26q1-omicscngenewgs-csv-normalization/4656/2 "2026-07-17T13:09:42Z")

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Hi,

OmicsCNGeneWGS contains copy number relative to the cell line’s ploidy, so you are correct that for an unaltered gene in a tetraploid line would be ~1.

Thanks,

Simone